In multiple imputation, the imputatin process is repeated multiple times resulting in multiple imputed datasets. Nonignorable missing data nonignorable missing data heckmans model for selection bias. Multiple imputation allows for uncertainty about the missing data by creating multiple copies of the data set in which missing values are replaced by imputed values sampled from a posterior predictive distribution, itself estimated from the partially observed data 5, 6, 10. Multiple imputation for continuous and categorical data. Further update of ice, with an emphasis on categorical variables. Multiple imputation involves more reading and writing to disk than most stata commands. Standard methods for imputing incomplete binary outcomes involve logistic regression or an assumption of multivariate normality, whereas relative risks are typically estimated. Multiple imputation has become very popular as a generalpurpose method for handling missing data. Multiple imputation has potential to improve the validity of medical research. M imputations completed datasets are generated under some chosen imputation. Multipleimputation analysis using statas mi command. Impute m values for each missing value creating m completed datasets.
A multiple imputation procedure developed by patrick royston can be installed directly through stata. Multiple imputation involves imputing m values for each missing cell in your data matrix and creating m completed data sets. Imputed datasets and multiple imputation analysis interaction terms and imputations importing data into micommand family stata has its own suite of commands for multiple imputation analysis. Statistics multiple imputation description mi impute chained. Distribution of missing data decide on the best analysis strategy to yield the least biased estimates deletion methods listwise deletion, pairwise deletion single imputation methods meanmode substitution, dummy variable method, single regression modelbased methods maximum likelihood, multiple imputation. Stata 11s mi command provides full support for all three steps of multiple imputation. Missing data that occur in more than one variable presents a special challenge.
Multiple imputation for handling missing outcome data when. Multiple imputation of missing values sage journals. This is part two of the multiple imputation in stata series. Multiple imputation variables multivariate imputation. In the 2017 nsch, missing values were imputed for several demographic variables used in the construction of survey weights. Assume a joint multivariate normal distribution of all variables. Multiple imputation of family income and personal earnings. Spss inc offers an addon package named pasw missing values that will implement mi.
Likelihood ratio testing after multiple imputation statalist. Finally, section 5 explains how to carry out multiple imputation and maximum likelihood using sas and stata. Berglund, university of michiganinstitute for social research abstract this presentation emphasizes use of sas 9. Multiple imputation of family income and personal earnings in. A note on bayesian inference after multiple imputation. Both methods were essentially unbiased across the repeated samples. Ive never done imputation myself in one scenario another analyst did it in sas, and in another case imputation was spatial mitools is nice for this scenario thomas lumley, author of mitools and survey. Child sex, race, and hispanic origin were imputed using hotdeck imputation while adult 1 education and household size were imputed using sequential regression imputation methods. This series is intended to be a practical guide to the technique and its implementation in stata, based on the questions sscc members are asking the ssccs statistical. Missing data in stata centre for multilevel modelling, 20 1 introduction to the youth cohort study dataset you will be analysing data from the youth cohort study of england and wales ycs1.
Missing data using stata basics for further reading many methods assumptions assumptions ignorability. Missing data and multiple imputation columbia university. Strategies for multiple imputation in longitudinal studies. Multiple imputation mi is a statistical technique for dealing with missing data. However, the method is still relatively rarely used in epidemiology, perhaps in part because relatively few studies have looked at practical questions about how to implement multiple imputation in large data sets used for diverse purposes. Mi stata multipleimputation reference manual mv stata multivariate statistics reference manual pss stata power, precision. Missing values cause observations to be omitted from analyses. Jul 31, 2015 multiple imputation was not originally designed to give good predictions see the discussion and literature in mi predict or a good overall fit, which is usually what one tries to asses when asking about the better model whatever that means rich has asked this crucial question.
Multiple imputation for missing data statistics solutions. Multiple imputation of bootstrap samples has been implemented in the analyses ofbriggs et al. Pdf multiple imputation of missing data researchgate. However, the multiple imputation procedure requires the user to model the distribution of each variable with missing values, in terms of the observed data. Missing data takes many forms and can be attributed to many causes. Multiple imputation for missing data in epidemiological and. Oct 07, 2011 multiple imputation seeks to solve that problem.
Multiple imputation is a robust and flexible option for handling missing data. When to use single imputation or multiple imputation. Multiple imputation regression imputation adding a random component multiple, random imputations combining the imputations. Background and terminology generating imputed datasets brief list of introductory references. This is a simple example and there are other commands and different ways to do multiple imputation, so you should do a lot more. Hi, i am using stata for analyzing clinical outcomes of some patients. While there is more than one type of single imputation, in general the process involves analyzing the other responses and looking for the most likely or a set of the most likely responses the. I am trying to do multiple imputation, however i am missing several values from several variables continuous data. This is a simple example and there are other commands and different ways to do multiple imputation, so you should do a lot more reading if you want to use mi yourself. The following is the procedure for conducting the multiple imputation for missing data that was created by. The validity of multipleimputationbased analyses relies on the use of an appropriate model to impute the missing values. Multiple imputation fills in missing values by generating plausible numbers derived from distributions of and relationships among observed variables in the data set.
This webpage is hosted by uclas institute for digital research and education. Across these completed data sets, the observed values are the same, but the missing values are filled in with different imputations that reflect our uncertainty about the missing data. I hope i can use some collected data from the incomplete variables to predict the missing data in those variables. Multiple imputation steps to do multiple imputation.
How to use spssreplacing missing data using multiple imputation regression method duration. Here, analysis of multiply imputed data is achieved by commands that start with mi. In this method the imputation uncertainty is accounted for by creating these multiple datasets. For longitudinal data as well as other data, mi is implemented following a framework for estimation and inference based upon a three step process. Multiple imputation is an effective method for dealing with missing data, and it is becoming increasingly common in many fields.
The basic idea of data analysis with multiple imputation is to create a small number e. Jun 29, 2009 multiple imputation has potential to improve the validity of medical research. Multiple imputation of missing values the stata journal. Despite the widespread use of multiple imputation, there are few guidelines available for checking imputation models. Multiple imputation using the fully conditional specification. For more information on multiple imputation in stata, type help mi. The multiple imputation process contains three phases. Thermuohp biostatistics resource channel 212,495 views 45. The spss base package does not include canned routines for conducting mi.
Before version 11, analysis of such data was possible with the help of ados. Imputation methods, and advanced methods, which cover multiple imputation, maximum likelihood, bayesian simulation methods and hotdeck imputation. Sometimes this includes writing temporary files in the current working directory. Bootstrap inference when using multiple imputation 3 with multiple imputation for particular analyses. Stata provides two approaches for imputing missing data. Multiple imputation mi was developed as a method to enable valid inferences to be obtained in the presence of missing data rather than to recreate the missing values. Analyze each of these m completed datasets separately. Description mi impute regress fills in missing values of a continuous variable using the gaussian normal regression imputation. The idea of multiple imputation for missing data was first proposed by rubin 1977. In order to use these commands the dataset in memory must be declared or mi set as mi dataset. Single imputation involves less computation, and provides the dataset with a specific number in place of the missing data. However, the usual advice for multiple imputation for modest fractions of.
Analysis model mi for panel data hip fracture example imputing clustered data in stata imputation with cluster dummies imputation in wide form imputation via random effects hip fracture example cont. The basic idea of data analysis with multiple imputation is. Multiple imputation provides a useful strategy for dealing with data sets with missing values. Stata has a suite of multiple imputation mi commands to help users not only impute their data but also explore the patterns of missingness present in the data. Aug 28, 2008 multiple imputation of family income and personal earnings in the national health interview survey.
Multiple imputations use simulation models that take from a set of possible responses, and impute in succession to try to come up with a varianceconfidence interval that one can use to better understand the differences between imputed datasets, depending on the numbers that the simulation. This particular page is the first of a two part series on implementing multiple imputation techniques in stata. Multiple imputation using the fully conditional specification method. Multiple imputation mi is an approach for handling missing values in a dataset that allows researchers to use. With a slight abuse of the terminology, we will use the. Multiple imputation for missing data is an attractive method for handling missing data in multivariate analysis. For a list of topics covered by this series, see the introduction the decision to use multiple imputation rather than simply analyzing complete cases should not be made lightly. Comparing joint and conditional approaches jonathan kropko university of virginia. Mice, multiple imputation, chained equations, fully conditional speci cation, gibbs sampler, predictor selection, passive imputation, r. Multiple imputation of missing data article pdf available in stata journal 43. Implementation in stata article pdf available in journal of statistical software 454 december 2011 with 1,579 reads how we measure reads. However, the sampling variance of the multiple imputation estimates was considerably smaller.
Multiple imputation of missing data using stata data and statistical. By imputing multiple times, multiple imputation certainly accounts for the uncertainty and range of values that the true value could have taken. Sep 06, 2017 multiple imputation is a popular approach to handling missing data in medical research, yet little is known about its applicability for estimating the relative risk. Multipleimputation inferences with uncongenial sources of input. Multiple imputation for missing data in epidemiological. Further update of ice, with an emphasis on interval censoring. Software using a propensity score classifier with the approximate bayesian boostrap produces badly biased estimates of regression coefficients when data on predictor. Having the data in wide form takes care of both the nesting issue there is now only one row of data per student and allows us to easily use variables from the other time periods as predictors of missing values, since in wide form, they are just other variables in the. An introduction to multiple imputation method for missing data analysis, and its application. For data analysis, this command often is a composite prefix mi which is followed by a standard stata command.
Stata 11 or higher the entire manual is available as a pdf file. Once we are familiar with our data, the first step in the imputation process is to reshape the data from long to wide. An imputation represents one set of plausible values for missing data, and so multiple imputations represent multiple sets of plausible values. Multiple imputation of family income and personal earnings in the national health interview survey. Introduction multiple imputation rubin1987,1996 is the method of choice for complex incomplete data problems. Multiple imputation in mplus employee data data set containing scores from 480 employees on eight workrelated variables variables. Mice stands for multivariate imputation by chained equations. Introduction in large datasets, missing values commonly occur in several variables. The validity of results from multiple imputation depends on such modelling being done carefully and appropriately. A comparison of sas, stata, iveware, and r patricia a. Directly maximize the parameter estimate using the observed cases and maximum likelihood method. In this paper, we provide an overview of currently. Missing data em algorithm and multiple imputation aaron molstad, dootika vats, li zhong university of minnesota school of statistics december 4, 20. Apr 29, 2017 how to use spssreplacing missing data using multiple imputation regression method duration.
In this article, we examine the approximation of gelman et al. Age, gender, job tenure, iq, psychological wellbeing, job satisfaction, job performance, and turnover intentions 33% of the cases have missing wellbeing scores, and 33% have missing satisfaction scores. Multiple imputation and panel data statalist the stata forum. Two algorithms for producing multiple imputations for missing data are evaluated with simulated data. A regression model is created to predict the missing values from the observed values, and multiple predicted values are generated for each missing value to create the multiple imputations. A new framework for managing and analyzing multiply imputed data. Use the fastest disk space available to you, both for your data set and for the working directory. Multiple imputation in stata, part 1 website overview. The answer is yes, and one solution is to use multiple imputation. Multiple imputation full information maximum likelihood conclusion principled methods methods that produce unbiased parameter estimates when assumptions are met estimates of uncertainty that account for increased variability due to missing values this presentation focuses on how to implement two of these methods stata multiple imputation mi.